Telaprevir to Boceprevir Switch Highlights Lack of Cross-Reactivity

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Telaprevir to boceprevir switch highlights lack of cross-reactivity.

Hepatitis C viral protease inhibitors increase sustained virologic response rates compared to interferon and ribavirin but also add side effects. Telaprevir and boceprevir are structurally similar, and share cross-resistant mutations. This case report highlights successful management of telaprevir skin rash and anal discomfort by switching to boceprevir.

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Managing Drug-Drug Interactions With Boceprevir and Telaprevir

The treatment of chronic hepatitis C virus (HCV) genotype 1 infection has been revolutionized by the introduction of direct-acting antiviral (DAA) agents (boceprevir and telaprevir) in combination with peginterferon and ribavirin. Although improved antiviral efficacy and shorter durations of therapy are anticipated, there are also potentially severe drug-drug interactions involving protease inh...

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Title : Lack of Allergic Cross - Reactivity between Fluconazole and Voriconazole

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ژورنال

عنوان ژورنال: Clinical Infectious Diseases

سال: 2012

ISSN: 1537-6591,1058-4838

DOI: 10.1093/cid/cis960